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In a 4-week phase 1 study using a MAD design in participants with T2D, comparing treatment against dulaglutide and placebo, target doses of 0.3 mg, 1.5 mg, and 4.5 mg achieve mean weight loss of 0.3%, 2.6%, and 3.0%, respectively, with 2.2% mean weight loss for the dulaglutide group and 1.0% for placebo ( 3.2.2 Oral 3.2.2.1 VK2735 Oral VK2735 is also being developed as an oral agent administered daily